Cholesterol modulates cellular TGF-β responsiveness by altering TGF-β binding to TGF-β receptors
نویسندگان
چکیده
منابع مشابه
TGF-β Signaling from Receptors to Smads.
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating cell proliferation, differentiation, death, and migration. The TGF-β family members signal via heteromeric complexes of type I and type II receptors, which activate members of the Smad family of signal transducers. ...
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Transforming growth factor-β (TGF-β) receptor oligomerization has important roles in signaling. Complex formation among type I and type II (TβRI and TβRII) TGF-β receptors is well characterized and is essential for signal transduction. However, studies on their interactions with the type III TGF-β coreceptor (TβRIII) in live cells and their effects on TGF-β signaling are lacking. Here we invest...
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TGF-β superfamily ligands play fundamental roles in the development and physiology of diverse animal species. Genetic and genomic analyses in the model organism Caenorhabditis elegans have contributed to the understanding of TGF-β-related signal transduction mechanisms. In this chapter, I describe the currently characterized TGF-β-related signals and signal transduction cassettes in C. elegans....
متن کاملTgf-β Signal Transduction
The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2008
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.21303